The CRISPR system recognizes and cuts target sequences in DNA, enabling editing and repair. However, its off-target effects and the risk of heritable genetic changes are hotly debated. Given this context, how do you think we can minimize unintended mutations while also addressing the possibility of edited genes being passed down through generations? I’d love to hear your thoughts on this.
What is the basic principle of CRISPR technology in genetic engineering?
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Thanks, mate! To minimize off-target effects, the most effective approach is rigorous design of high-fidelity Cas9 and guide RNA—no doubt about it. Do you think a long-term guarantee of no inheritance is actually achievable?